Scientific Results

This catalogue is obtained by conducting a systematic literature review of scientific studies and reviews related to monitoring, forecasting, and simulating the inland water cycle. The analysis maps scientific expertise across research groups and classifies findings by the type of inland water studied, application focus, and geographical scope. A gap analysis will identify missing research areas and assess their relevance to policymaking.

ID â–² Type Year Authors Title Venue/Journal DOI Research type Water System Technical Focus Abstract Link with Projects Link with Tools Related policies ID
publications-1371 PEER REVIEWED ARTICLE 2017 Juliane Hollender , Emma L. Schymanski , Heinz P. Singer , P. Lee Ferguson Nontarget Screening with High Resolution Mass Spectrometry in the Environment: Ready to Go? 10.1021/acs.est.7b02184 Data Management & Analytics Precipitation & Ecological Systems No abstract available 603437
publications-1372 PEER REVIEWED ARTICLE 2018 Hélène Serra , François Brion , Jean-Marc Porcher , Hélène Budzinski , Selim Aït-Aïssa Triclosan Lacks (Anti-)Estrogenic Effects in Zebrafish Cells but Modulates Estrogen Response in Zebrafish Embryos 10.3390/ijms19041175 Simulation & Modeling Precipitation & Ecological Systems Triclosan (TCS), an antimicrobial agent widely found in the aquatic environment, is suspected to act as an endocrine disrupting compound, however mechanistic information is lacking in regards to aquatic species. This study assessed the ability of TCS to interfere with estrogen receptor (ER) transcriptional activity, in zebrafish-specific in vitro and in vivo reporter gene assays. We report that TCS exhibits a lack of either agonistic or antagonistic effects on a panel of ER-expressing zebrafish (ZELH-zfERα and -zfERβ) and human (MELN) cell lines. At the organism level, TCS at concentrations of up to 0.3 µM had no effect on ER-regulated brain aromatase gene expression in transgenic cyp19a1b-GFP zebrafish embryos. At a concentration of 1 µM, TCS interfered with the E2 response in an ambivalent manner by potentializing a low E2 response (0.625 nM), but decreasing a high E2 response (10 nM). Altogether, our study suggests that while modulation of ER-regulated genes by TCS may occur in zebrafish, it does so irrespective of a direct binding and activation of zfERs. 603437
publications-1373 PEER REVIEWED ARTICLE 2018 Manoj Sonavane , Jennifer E. Schollée , Anita O. Hidasi , Nicolas Creusot , François Brion , Marc J.-F. Suter , Juliane Hollender , Selim Aїt-Aїss An integrative approach combining passive sampling, bioassays, and effect-directed analysis to assess the impact of wastewater effluent 10.1002/etc.4155 Data Management & Analytics Precipitation & Ecological Systems Abstract   Wastewater treatment plant (WWTP) effluents are major sources of endocrine-disrupting chemicals (EDCs) and other chemicals of toxicological concern for the aquatic environment. In the present study, we used an integrated strategy combining passive sampling (Chemcatcher®), developmental toxicity, and mechanism-based in vitro and in vivo bioassays to monitor the impacts of a WWTP on a river. In vitro screening revealed the WWTP effluent as a source of estrogen, glucocorticoid, and aryl hydrocarbon (AhR) receptor-mediated activities impacting the downstream river site where significant activities were also measured, albeit to a lesser extent than in the effluent. Effect-directed analysis of the effluent successfully identified the presence of potent estrogens (estrone, 17α-ethinylestradiol, and 17β-estradiol) and glucocorticoids (clobetasol propionate and fluticasone propionate) as the major contributors to the observed in vitro activities, even though other unidentified active chemicals were likely present. The impact of the WWTP was also assessed using zebrafish embryo assays, highlighting its ability to induce estrogenic response through up-regulation of the aromatase promoter-dependent reporter gene in the transgenic (cyp19a1b–green fluorescent protein [GFP]) zebrafish assay and to generate teratogenic effects at nonlethal concentrations in the zebrafish embryo toxicity test. The present study argues for the use of such an integrated approach, combining passive sampling, bioassays, and effect-directed analysis, to comprehensively identify endocrine active compounds and associated hazards of WTTP effluents. Environ Toxicol Chem 2018;37:2079–2088. © 2018 SETAC 603437
publications-1374 PEER REVIEWED ARTICLE 2019 K.M. Unice , M.P. Weeber , M.M. Abramson , R.C.D. Reid , J.A.G. van Gils , A.A. Markus , A.D. Vethaak , J.M. Panko Characterizing export of land-based microplastics to the estuary - Part I: Application of integrated geospatial microplastic transport models to assess tire and road wear particles in the Seine watershed 10.1016/j.scitotenv.2018.07.368 Simulation & Modeling Precipitation & Ecological Systems No abstract available 603437
publications-1375 PEER REVIEWED ARTICLE 2019 K.M. Unice , M.P. Weeber , M.M. Abramson , R.C.D. Reid , J.A.G. van Gils , A.A. Markus , A.D. Vethaak , J.M. Panko Characterizing export of land-based microplastics to the estuary - Part II: Sensitivity analysis of an integrated geospatial microplastic transport modeling assessment of tire and road wear particles 10.1016/j.scitotenv.2018.08.301 Data Management & Analytics Precipitation & Ecological Systems No abstract available 603437
publications-1376 PEER REVIEWED ARTICLE 2017 Mikael B. Gustavsson , Andreas Hellohf , Thomas Backhaus Evaluating the environmental hazard of industrial chemicals from data collected during the REACH registration process 10.1016/j.scitotenv.2017.02.039 Simulation & Modeling Stratosphere No abstract available 603437
publications-1377 PEER REVIEWED ARTICLE 2017 B. Mikael Gustavsson , Jörgen Magnér , Bethanie Carney Almroth , Martin K. Eriksson , Joachim Sturve , Thomas Backhaus Chemical monitoring of Swedish coastal waters indicates common exceedances of environmental thresholds, both for individual substances as well as their mixtures 10.1016/j.marpolbul.2017.06.082 IoT & Sensors Stratosphere No abstract available 603437
publications-1378 PEER REVIEWED ARTICLE 2017 Mikael Gustavsson , Jenny Kreuger , Mirco Bundschuh , Thomas Backhaus Pesticide mixtures in the Swedish streams: Environmental risks, contributions of individual compounds and consequences of single-substance oriented risk mitigation 10.1016/j.scitotenv.2017.04.122 Simulation & Modeling Stratosphere No abstract available 603437
publications-1379 PEER REVIEWED ARTICLE 2017 Jakob Menz , Ewelina Baginska , Åsa Arrhenius , Annette Haiß , Thomas Backhaus , Klaus Kümmerer Antimicrobial activity of pharmaceutical cocktails in sewage treatment plant effluent – An experimental and predictive approach to mixture risk assessment 10.1016/j.envpol.2017.09.009 Simulation & Modeling Stratosphere No abstract available 603437
publications-1380 PEER REVIEWED ARTICLE 2019 K.M. Unice , M.P. Weeber , M.M. Abramson , R.C.D. Reid , J.A.G. van Gils , A.A. Markus , A.D. Vethaak , J.M. Panko Characterizing export of land-based microplastics to the estuary - Part I: Application of integrated geospatial microplastic transport models to assess tire and road wear particles in the Seine watershed 10.1016/j.scitotenv.2018.07.368 Simulation & Modeling Precipitation & Ecological Systems No abstract available 603437